Three Global Conditions for Biodiversity Conservation and Sustainable Use (3Cs) is an implementation framework suitable for use in the Post-2020 Strategic Plan. It follows the well-known drivers-state-pressure-response approach for addressing biodiversity conservation on land. A compatible marine approach is under development. The 3Cs framework evaluates land-use drivers and human pressures to establish a baseline state of three broad terrestrial conditions: Cities and Farms cover 18% of land (C1), shared lands 56% (C2), and large wild areas 26% (C3). It maps all but Antarctica and enables development of suites of conservation responses and production practices appropriate for each condition that are clustered on a continuum from those appropriate to the most heavily impacted areas to those best suited to the wildest areas remaining on Earth.